epidemiologic study of the role of exogenous and endogenous estrogens in rheumatoid arthritis by Louise Murphy

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StatementLouise Murphy.
The Physical Object
Pagination171 leaves.
Number of Pages171
ID Numbers
Open LibraryOL19758308M
ISBN 109780494159101

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Collagen-induced arthritis (CIA) is an often-used murine model for human rheumatoid arthritis (RA). Earlier studies have shown potent anti-arthritic effects with the female sex hormone estradiol and the selective estrogen receptor modulator (SERM) raloxifene in CIA in DBA/ by: 8.

Endogenous and exogenous estrogen, and raloxifene treatment lowered the serum levels of IL Increased serum IL-6 in arthritis is a marker of the general inflammatory disease. The serum levels of IL-6 were significantly lower (P Cited by: 8. The Rotterdam study is the only large single-population based study to report whether endogenous estrogens predict future dementia in older non-demented women.

Higher levels of total estradiol were associated with an increased 6 year risk of dementia (age-adjusted hazard ratio per standard deviation increase ; 95% CI ); results were similar for (calculated) bioavailable by: Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in BQ-ncf1*/* mice with collagen-induced chronic arthritis Rheumatoid arthritis (RA) is a joint destructing autoim-mune disease affecting % of the adult population [1,2].

The distribution between men and women is ,Cited by: 8. Epidemiology is the study of the distribution and determinants of disease in human populations. 21 This definition is based on two fundamental assumptions: first, that human disease does not occur at random and, second, that human disease has causal and preventive factors that can be identified through systematic investigation of different populations or subgroups of individuals within a Cited by: The epidemiology of Rheumatoid arthritis.

of exogenous or endogenous in nature which medications used to reduce rheumatoid arthritis's symptoms. This study will Author: Sherine Gabriel. Influence of female hormonal factors, in relation to autoantibodies and genetic markers, on the development of rheumatoid arthritis in Northern Sweden: a case–control by: Endogenous and Exogenous Estrogen, Cognitive Function, and Dementia in Postmenopausal Women: Evidence from Epidemiologic Studies and Clinical Trials.

Multiple hypotheses, based on laboratory experiments, exist about the role of specific estrogen metabolites and estrogen metabolism profiles in the etiology of breast cancer.Both estrogen receptor-mediated mechanisms involving increased mitosis and proliferation and estrogen receptor-independent mechanisms involving direct DNA damage have been by: Although the systemic and local effects of exogenous (i.e., pharmacologic) GCs have been studied extensively, little is known about epidemiologic study of the role of exogenous and endogenous estrogens in rheumatoid arthritis book role of endogenous GCs in the development and perpetuation.

The estrogens from exogenous sources may display a synergic/additive effect with that of endogenous molecules and theoretical may display sensitive effects on the immune responses.

Because of the predominance of females in autoimmune diseases, it should also be taken into consideration the role of estrogens of therapeutic sources, i.e., oral Cited by: Background.

Collagen-induced arthritis (CIA) is an often-used murine model for human rheumatoid arthritis (RA). Earlier studies have shown potent anti-arthritic effects with the f.

Int J Cancer38, Ewertz IVI. Influence of non-contraceptive exogenous and endogenous sex hormones on breast cancer risk in Denmark. Int J Cancer42, Hulka BS. Effect of exogenous estrogen on postmenopausal women: the epidemiologic evidence.

Obstet Gynecol Sura35, Cited by: Rheumatoid arthritis (RA) is a joint destructing autoimmune disease affecting % of the adult population [1, 2].The distribution between men and women iswith a peak incidence during menopause and in the post-partum period [].Several studies, including a population-based case-control study [], have investigated whether the use of oral contraceptives could have an impact on the Cited by: 8.

A review of available experimental, clinical, and epidemiologic data suggests that in addition to estrogens, other endogenous hormones, including progesterone, androgens, gonadotropins, prolactin, insulin, and insulin‐like growth factors, may play a role in the pathogenesis of different histopathologic types of endometrial by: Only one epidemiologic cohort, the NHS, has been used to study the role of exogenous estrogens in SLE etiology.

The NHS was assembled in and includesfemale registered nurses aged 30–55 years living in 11 states who are contacted for updated exposures and other data every 2 years and in between for supplementary information when Cited by: Rheumatoid arthritis (RA) is a chronic disease with prevalence of ∽–1% of the adult population in most Western countries ().The etiology of this disease is only partly explained by genetic factors, and it has been suggested that environmental factors may play a significant role ().Changes over time in the incidence and in the age and sex distributions of RA might implicate specific Cited by: Start studying Ch Women's Health Drugs.

Learn vocabulary, terms, and more with flashcards, games, and other study tools. Search. exogenous compounds (from a source outside our bodies) describe estrogen receptors.

because most of the endogenous estrogens are inactive when taken orally. Estrogen metabolites have been implicated in rheumatoid arthritis (RA) and cancer, although the mechanism remains unestablished.

Some estrogen metabolites, which are used for the assessment of cancer risk, play an important role in RA. The pathways by which malignancies associated with RA remain by: 3. Inactivation of the Biological Effects of Exogenous and Endogenous Estrogens by Antibodies to 17 B cells in rheumatoid arthritis synovial tissues encode focused antibody repertoires that include antibodies that stimulate macrophage TNF-α by: Tosato, G., Steinberg, D., and Yarchoan R.

() Abnormally elevated frequency of Epstein-Barr virus-infected B cells in the blood of patients with rheumatoid arthritis. : Constantin Bona, Chihiro Murai, Takeshi Sasaki.

The aim of this review was to appraise data from recent research concerning female hormonal factors and their association with RA disease development. The study of female hormonal factors is challenging because serum levels may differ throughout a woman's lifetime.

Exogenous Hormone Use: Oral Contraceptives, Postmenopausal Hormone Therapy, and Health Outcomes in the Nurses’ Health Study. At the time of study, Shilpa N. Bhupathiraju, Meir J. Stampfer, Walter C.

Willett, and Frank B. Hu were with the Department of Nutrition, Harvard T. Chan School of Public Health, Boston, by: Effect of endogenous and exogenous hormones on testicular cancer: the epidemiological evidence FABRIZIO GIANNANDREA 1, DONATELLA PAOLI, IRENE FIGÀ-TALAMANCA2, FRANCESCO LOMBARDO 1, ANDREA LENZI and LOREDANA GANDINI1 1Department of Experimental Medicine, Laboratory of Seminology - Semen Bank, University of Rome "La Sapienza", Rome, Italy and.

RESULTS: Raloxifene and estradiol treatment, as well as endogenous estrogen, decreased the frequency of arthritis, prevented joint destruction and countered generalized osteoporosis. These effects were associated with lower serum Cited by: 8. The role of hormones in the pathogenesis of psoriasis vulgaris.

Several exogenous factors and endogenous hormonal changes may act as triggers for psoriasis. epidemiological study on. Expanding on our research evaluating endogenous estrogens and estrogen metabolites and cancer risk, recent methodologic advances in the measurement of androgens and androgen metabolites as well as progesterone, pregnenolone, and progesterone metabolites in serum will facilitate epidemiologic studies to evaluate the role of principal estrogens.

Estrogen indications. To treat or prevent disorders that result from an estrogen deficiency. E.g. Atrophic vaginitis, hypogonadism, oral contraception (given with a progestin), uterine bleeding, vasomotor spasms of menopause/"hot flashes," osteoporosis treatment.

The study of Janele et al, ] demonstrates that ratio of hydroxylated estrogen in relation to 2-/4-hydroxylated estrogen is important for TNF secretion. It has been found that the ratio of of OHE 2 in relation to 2-/4- hydroxylated estrogen markedly stimulated TNF secretion in presence of cortisol ( Cited by: 2.

In addition, new epidemiologic evidence has indicated that among the metabolic factors, glucose metabolism, hyperinsulinemic insulin resistance, and insulin-like growth factor bioavailability may also play a role in breast cancer. These endocrine and metabolic factors may represent future targets for breast cancer by: Given the suggested role of endogenous sex hormones in RA, it is possible that exposure to preparations containing exogenous gonadal hormones, such as oral contraceptives (OC) or estrogen replacement therapy (ERT), may also influence RA development.

A number of epidemiological investigations investigated whether exogenous estrogens in. The pathogenesis of rheumatoid arthritis is poorly understood; however, elevated oxidative stress has been described to be involved. In this chapter, we present experiments with endogenous molecules bearing antioxidative properties.

In our studies, we used male Lewis rats, and the arthritis was induced with Mycobacterium butyricum. In the first experiment, we tested coenzyme Q 10 (CoQ 10) in Author: Katarina Bauerova, Jarmila Kucharska, Silvester Ponist, Lukas Slovak, Karol Svik, Vladimir Jakus, Ja.

Epidemiologic studies suggest that endogenous testosterone levels are positively associated with breast cancer risk in postmenopausal women. Given the increasing trend in the use of hormone therapies containing androgens, we evaluated the relation between the use of estrogen and testosterone therapies and breast by:   Daily pattern of rheumatoid arthritis symptoms for serum concentrations of IL Proinflammatory hormones (that is, melatonin) start to rise during the early night before the onset of rheumatoid arthritis symptoms and before the endogenous cortisol rise in these patients.

Grey shading, trigger time for the IL-6 by:   The aim of the present study was to assess the potential of exogenous and endogenous nucleic acids to trigger joint inflammation in a healthy joint.

Materials and methods Isolated and highly purified bacterial DNA, viral dsRNA, and endogenous mitochondrial (mt) and nuclear DNA, as well as synthetically produced homologues of these molecules Cited by: 1.

However, any epidemiologic study of endogenous hormones must take into account sources of exogenous exposure that may influence endogenous hormone levels. Examples/case studies Sex steroids and breast cancer risk in postmenopausal women Substantial data support a role of hormones, particularly sex steroids, in the etiology of breast Size: KB.

What is the difference between an exogenous and an endogenous antigen. exogenous - antigen in blood plasma, interstitial fluid or lymph, can be (bacteria, virus, inhaled pollen, parasitic worm) endogenous - invaded body cells (virus, toxins, abnormal proteins), MHC I with antigen fragment on.

The Role of Epidemiology in the Era of Molecular Epidemiology and cell-based inflammatory response in a specific tissue, such as in skeletal joints in rheumatoid arthritis or in coronary plaques in atherosclerosis.

aspirin and risk of Reye's syndrome, and high exogenous and endogenous estrogens and breast cancer. Epidemiology remains Cited by: Epidemiology is the study of the frequency and distribution of diseases and factors related to the development of diseases.

Systemic lupus erythematosus (SLE) is a rare, chronic inflammatory autoimmune disease that affects many tissues and organs, whose female-to-male incidence ratio is for childbearing age.

Its chronic intractable nature has a significant impact on medical care Author: Masakazu Washio, Chikako Kiyohara, Akiko Ohta. Women of childbearing age and those in the postmenopausal period constitute a major proportion of the total population.

Inmillion women in the United States were in the reproductive age range of 15 to 50 years, 1 and as ofapproximately 64 million women in the United States were postmenopausal. 2 Among fertile women, oral contraceptives (OCs) are among the most Cited by:.

The pathophysiology is the basis for different diagnostic and therapeutic strategies, i.e. in the first case a stimulated LH/FSH ratio >1 and suppressive treatment with GnRH agonists (e.g. in hypothalamic hamartoma), and in the second decreased gonadotrophins and removal or suppression of the endogenous or exogenous sex steroid source (e.g Cited by:   To determine the role of endogenous glucocorticoids in bone growth and maintenance, and its dependence on age, sexual maturity, gender and skeletal site, 3 Cited by:   The role of the female hormone estrogen in two predominantly female autoimmune diseases — multiple sclerosis and systemic lupus erythematosus — is the focus of a recent review study, “ The Immune System Is a Natural Target for Estrogen Action: Opposing Effects of Estrogen in Two Prototypical Autoimmune Diseases.

” The study was published in the Frontiers in Immunology journal.

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